A leading social neuroscientist mines decades of research to show how prolonged loneliness affects the body and mind. The book explains links between social isolation and immune function, stress hormones, gene expression and cognitive performance, drawing on brain imaging and physiological studies.

Tracing the evolutionary roots of human sociality, the author argues that our need for connection shaped survival and behaviour. Persistent isolation can distort social perception and emotion regulation, creating a self-reinforcing cycle of withdrawal.

Combining science and practical insight, the book outlines ways individuals and communities can repair frayed bonds to support better health and psychological resilience.

Key insights

• Biological effects of loneliness on health
• How social signals and behaviour change under isolation
• Strategies to rebuild meaningful connection

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